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In-Context Multiple Instance Learning

Alexander Möllers, Marvin Sextro, Julius Hense, Gabriel Dernbach, Klaus-Robert Müller

Published
Jun 4, 2026 — 17:50 UTC

Problem
This work addresses the limitations of existing Multiple Instance Learning (MIL) algorithms, particularly in low-label regimes prevalent in real-world applications. Current methods either overfit due to their flexibility or fail to generalize due to rigidity. The authors highlight the need for a robust approach that can effectively utilize limited labeled data while maintaining adaptability across various tasks. This paper is a preprint and has not undergone peer review.

Method
The authors propose a novel in-context learning framework utilizing a Perceiver-style architecture, which is pretrained on synthetic data generated from various data generators tailored for bag-structured data. The model is designed to perform classification in a single forward pass during inference, eliminating the need for gradient updates. The synthetic data generators are shown to capture complementary inductive biases, and the model benefits from a mixture of these generators during pretraining. The training process involves leveraging diverse synthetic datasets to enhance the model’s ability to generalize across different MIL tasks.

Results
The proposed model achieves superior performance across twelve MIL benchmarks, significantly outperforming traditional supervised baselines that require task-specific training. The authors report an average performance improvement of approximately 15% over the best-performing supervised methods, demonstrating the effectiveness of their approach in leveraging synthetic data for low-label scenarios. Specific benchmark comparisons and performance metrics are provided, showcasing the model’s robustness and adaptability.

Limitations
The authors acknowledge that the reliance on synthetic data may not fully capture the complexities of real-world data distributions, potentially limiting the model’s performance in certain applications. Additionally, the paper does not address the computational cost associated with generating synthetic data or the potential biases introduced by the data generation process. The generalizability of the model to tasks outside the tested benchmarks remains an open question.

Why it matters
This research has significant implications for advancing the field of Multiple Instance Learning, particularly in scenarios where labeled data is scarce. By demonstrating the efficacy of in-context learning with synthetic data, the authors provide a pathway for developing more flexible and robust MIL models that can adapt to various tasks without extensive retraining. This work contributes to the ongoing discourse on leveraging synthetic data in machine learning, as discussed in related literature, and is available on arXiv.

Turing Wire

By Turing Wire editorial staff · Jun 4, 2026 · Editorial standards →

Source: arXiv cs.LG